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Cordyceps sinensis, the main ingredient in CORDYTHAI with Collagen

Cordyceps Benefits

Related to virus suppressor

  • Ryu, E, Son, M, Lee, M, Lee, K, Cho, JY, Cho, S, … Kang, H. (2014) Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication. Oncoscience, 1(12): 866–881.
  • Zhang, H.; Saravanan, K.M.; Yang, Y.; Hossain, M.T.; Li, J.; Ren, X.; Wei, Y. Deep Learning Based Drug Screening for Novel Coronavirus 2019-nCov. Preprints 2020, 2020020061.

Related to immunity and cancer studies

  • Nakamura K, Shinozuka K, Yoshikawa N. (2015) Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. Journal of Pharmacological Sciences. 127(1): 53-56.
  • Niwa Y, Matsuura H, Murakami M, Sato J, Hirai K, Sumi H. (2013) Evidence that Naturopathic Therapy including Cordyceps sinensis Prolongs Survival of Patients with Hepatocellular Carcinoma. Integr Cancer Ther. 12(1): 50-68.
  • Choi S, Lin MH, Kim KM, Jeon BH, Song WO, Kim TW. (2011) Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor. Toxicol ApplPharmacol. 257(2): 165-173.
  • Yoshikawa N, Nakamura K, Yamaguchi Y, Kagota S, Shinozuka K, Kunitoma M. (2007) Cordycepin and Cordyceps sinensis reduce the growth of the human promyelocytic leukaemia cells through the Wnt signaling pathway. Clin Exp Pharmacol Physiol. 34: S61-S63.
  • Kuo YC, Lin CY, Tsai WJ, WU CL, Chen CF, Shiao MS. (1994) Growth inhibitors against tumor cells in Cordyceps sinesis other than cordycepin and polysaccharides. Cancer Invest. 12(6): 611-615.

Cordyceps Benefits on Increased Oxygen at tissue level (i.e. Hypoxia)

  • Singh M, Tulsawani R, Koganti P, Chauhan A, Manickam M, Misra K. (2013) Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells. BioMed Research International. 2013, 569206.

Cordyceps Benefits on Exercise Performance (Anti-fatigue)

  • Xu YF. (2016) Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming. Int J Med Mushrooms. 18(12):1083-1092. 10.1615/IntJMedMushrooms.v18.i12.30
  • Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. (2010) Effect of Cs-4®(Cordyceps sinensis) on exercise performance in healthy older subjects : A double-blind, Placebo-Controlled Trial. J Altern Complement Med. 16(5): 585-590.
  • Nagata A, Tajima T, Uchida M. (2006) Supplemental anti-fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human. Jpn J Phys Fitness Sports Med. 55: 145-151.

Cordyceps Benefits on Kidney function

  •  Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. (2014) Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease. Cochrane Database of Systematic Reviews. Issue 12. Art. No.: CD008353.
  • Xu FL, Huan WY, Wu TX, Qiu X, Zhang H, Liu XH. (2006) Clinical efficacy of Cordyceps sinensis for chronic kidney diseases: a systematic review. Chinese Journal of Evidence-Based Medicine. 6(11): 804-808.
  • Zhu JG, Halpern G, Jones K. (1998) The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordycep sinensisThe Journal of Alternative and Complimentary Medicine. 4(3): 289-303, 429-457.

Cordyceps Benefits on Liver Functions

  • Gong HY, Wang KQ, Tang SG. (2000) Effects of Cordyceps sinensis on T lymphocyte subsets and hepatic fibrosis in patients with chronic hepatitis B. Hunan Yi Ke Da Xue Xue Bao. 25: 248-250.
  • Zhao SL. (2000) Advance of treatment for Cordyceps on chronic hepatic diseases. Shanxi Zhong Yi. 16: 59-60.

Cordyceps Benefits on Immunosuppressive Therapy

  • Li Y, Xue WJ, Tian PX, Ding XM, Yan H, Pan XM, Feng XS. (2009) Clinical Application of Cordyceps sinensis on Immunosuppressive Therapy in Renal Transplantation. Tranplant Proc. 41(5): 1565-1569.

Cordyceps Benefits on Respiratory Pathway

  • Ma X, Jiao X, Wu J, Zhao J, Xu Y, Liu T, Xu J, Yang L, Dong L. (2018) The Function of Ophiocordyceps sinensis in Airway Epithelial Cell Senescence in a Rat COPD Model. Canadian Respiratory Journal2018, 6080348.
  • Liu A, Wu J, Li A, Bi W, Liu T, Cao, L, Lui Y, Dong L. (2016) The inhibitory mechanism of Cordyceps sinensis on cigarette smoke extract-induced senescence in human bronchial epithelial cells. International Journal of Chronic Obstructive Pulmonary Disease. 11: 1721–1731.

Cordyceps Benefits on arthritis

  • Noh E-M, Kim J-S, Hur H, Park B-H, Song E-K, Han M-K, Kwon K-B, Yool W-H, Shim -K, Lee SJ, Youn HJ, Lee Y-R. (2009) Cordycepin inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology. 48(1): 45–48.

Cordyceps Benefits on Male Reproductive System

  • Chen Y-C, Chen Y-H, Pan B-S, Chang M-M, Huang B-M. (2017) Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review. Journal of Food and Drug Analysis. 25(1) :197-205.

Cordyceps Benefits related to UVB protection on Skin

  • Wong WC, WC JY, Benzie IF. (2011) Photoprotective potential of Cordyceps Polysaccharides against ultraviolet B radiation-induced DNA damage to human skin cells. Br J Dermatol. 164(5): 980-986. 
  • Lee YR, Noh EM, Jeong EY, Yun SK, Jeong YJ, Kim JH, Kwon KB, Kim BS, Lee SH, Park CS, Kim JS. (2009) Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-KB pathway in human dermal fibroblast. Exp Mol Med. 41(8): 548-554.

Cordyceps Benefits on Anti-inflammation

  • Park S-Y, Jung S-J, Ha K-C, Sin H-S, Jang S-H, Chae H-J, Chae S-W (2015) Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages. Oriental Pharmacy and Experimental Medicine. 15(1): 7–12.
  • Yang ML, Kuo PC, Hwang TL, Wu TS. (2011) Anti-inflammatory principles from Cordyceps sinensis. J Nat Prod.74 (9): 1996-2000.
  • Li CY, Chiang CS, Tsai ML, Hseu RS, Shu WY, Chuang CY, Sun YC, Chang YS, Lin JG, Chen CS, Huang CL, Hsu IC. (2009) Two-sided effect of Cordyceps sinensis on dendritic cells in different physiological stages. J Leukoc Biol. 85(6): 987-995. 

Cordyceps Benefits on Anti-oxidation

  • Li SP, Li P, Dong TTX, Tsin KW. (2001) Anti-oxidant activity of different type of natural Cordyceps sinensis and cultured Cordyceps mycelia. Phytomedicine. 8(3): 207-212.

Cordyceps Benefits on cholesterol by lowering LDL

  • Gao J, Lian ZQ, Zhu P, Zhu HB. (2011) Lipid-lowering effect of cordycepin (3′-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats. Yao Xue Xue Bao. 46(6): 669-76.
  • Guo P, Kai Q, Gao J, Lian ZQ, Wu CM, Wu CA, Zhu HB. (2010) Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharmacol Sci. 113(4): 395-403.
  • Koh J-H, Kim J-M, Chang U-J, Suh H-J. (2003) Hypocholesterolemic Effect of Hot-Water Extract from Mycelia of Cordyceps sinensisBiological and Pharmaceutical Bulletin. 26(1): 84-87.

Cordyceps Benefits on Blood Sugar

  • Yu SH, Chen SY, Li WS, et al. (2017) Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice. J Diabetes Res. 2017:7947401.
  • Liu C, Song J, Teng M, Zheng X, Li X, Tian Y, Pan M, Li Y, Lee RJ, Wang D.(2016) Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps militaris Fruit Body in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Oxidative Medicine and Cellular Longevity. E-Pub 2016:9685257: 11 pp.
  • Lo HC, Tu ST, Lin KC, Lin SC. (2004) The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin. Life Sci. 74(23): 2897-2908.



Black Ginger (Krachidam กระชายดำ) one of the ingredients in CORDYTHAI with Black Ginger

Black Ginger, Beta Glucan, Glutathione and Arginine Benefits

Glutathione Benefits

Matsuki M, Watanabe T, Ogasara A, Mikami T, Matsumoto T. (2008) Inhibitory Mechanism of Melanin Synthesis by Glutathione. Yakugaku Zasshi. 128(8): 1203-1207.

Collagen Benefits

Moskowitz R. (2000) Role of collagen hydrolysate in bone and joint disease. Seminass in arthritis and rheumatism. 30(2): 87-99.

Arginine Benefits

Roth AJ, Muller O, Schopohl J, von Werder K. (1998) Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 67(6): 1186-1189.

Glucan Benefits

Vetvika V, Dvorak B, Vetvickova J, Richter J, Krizan J, Sima P, Yvin JC. (2007) Orally administered marian (1,3)-beta-D-Glucan Phycarine stimulates both humoral and cellular immunity. Intl J Biol Macromolec. 40(4): 291-298.

Kirmaz C, Bayrak P, Yilmaz O, Yuksel H. (2005) Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis : a double-blind placebo-controlled study. European cytokine network. 16(2): 128-134.

Black Ginger (KraChaiDam) Benefits

Toda, K., Hitoe, S., Takeda, S., & Shimoda, H. (2016). Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolism. Heliyon2(5), e00115.

Temkitthawon P, Hinds TR, Beavo JA, Viyoch J, Suwanborirux K, Pongamornkul W, Sawasdee P, Ingkaninan K. (2011). Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. Journal of Ethnopharmacology. 137(3): 1437–1441.

Pojanagaroon S, Rujjanawate C. (2005) Effect of internal color of Kaempferia parviflora (Krachai-Dam) rhizomes as raw materials for wine processing on anti-oxidative activity. Processding of 43rd Kasetsart University Annual Conference. Thailand. 1-4 February.

Black sesame seeds, source of sesamin. One of the ingredients in CENTRO joint support

Sesame with Gotu Kola, Collagen type II and Soy Protein Isolate

Srisuthtayanont W, Pruksakorn D, Kongtawelert P, Pothacharoen P. (2017) Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes. BMC Complementary and Alternative Medicine. 17:286.

Khansai M, Boonmaleerat K, Pothacharoen P, Phitak T, Kongtawelert P. (2016) Ex vivo model exhibits protective effects of sesamin against destruction of cartilage induced with a combination of tumor necrosis factor-alpha and oncostatin M. BMC Complementary and Alternative Medicine16:205.

Sharma S, Gupta R, Thakur SC. (2014) Attenuation of collagen induced arthritis by Centella asiatica methanol fraction via modulation of cytokines and oxidative stress. Biomed Environ Sci.27(12):926-38.

Crowley DC, Lau FC, Sharma P. (2009) Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. International J of Med Sciences. 6:312-321.

Hyun TH, Barrett-Connor E, Milne DB. (2004) Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study. The American Journal of Clinical Nutrition. 80(3): 715–721.

Bagchi D, Misner B, Bagchi M, Kothari SC. (2002) Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 22(3-4):101-110.

Ausar S, Beltramo D, Castagna L, Quintana S. (2001) Treatment of rheumatoid arthritis by oral administration of bovine tracheal type II collagen. Rheumat Intern. 20(4):138-144.

Garcia G, Komagata Y, Slavin A, Maron R, Weiner H. (1999) Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen. J of Autoimmunity. 13(3): 315-324.

Chavali R, Zhong SW, Tsunomiya WU, Robert TF. (1997) Decreased Production of lnterleukin-1-Beta, Prostaglandin-E2 and Thromboxane-B2, and Elevated Levels of lnterleukin-6 and -10 Are Associated with Increased Survival during Endotoxic Shock in Mice Consuming Diets Enriched with Sesame Seed Oil Supplemented with Quil-A Saponin. International archives of allergy and immunology. 114.

Bonte F, Dumas M, Chaudagne C, Meybeck A. (1994) Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. Planta Med. 60(2):133-135.

Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D. (1993) Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 261(5129):1727-1730.

Chamomile flower one of the natural ingredients in PABLO natural sleep aid

Sesame, Rice bran, Chamomile flower with Cordyceps, Green tea and Black pepper

Isadora Braga Contreiras Carneiro, Ana Elisa Toscano, Diego Cabral Lacerda, Marcela de Sá Barreto da Cunha, Raul Manhães de Castro, Tereza Cristina Bonfim de Jesus Deiró, Jairza Maria Barreto Medeiros. (2018) L-tryptophan administration and increase in cerebral serotonin levels: Systematic review. European Journal of Pharmacology. Article in Press.

Zhigang L, Liu X, Luo S, Chu C, Wu D, Liu R, Wang L, Wang J, Liu X. (2018) Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits. Journal of Functional Foods. 42:237-247.

Adib-Hajbaghery M, Mousavi SN. (2017) The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complementary Therapies in Medicine. 35:109-114.

Bjorness TE, Greene RW. (2017) Chapter 6 – Sleep, Adenosine, and Neurodegeneration. Editor(s): David Blum, Luísa V. Lopes. Adenosine Receptors in Neurodegenerative Diseases. Academic Press. 111-130.

Greene RW, Bjorness TE, Suzuki A. (2017) The adenosine-mediated, neuronal-glial, homeostatic sleep response. Current Opinion in Neurobiology. 44:236-242.

Shi M-M, Piao J-H, Xu X-L, Zhu LC, Yang L, Lin F-L, Chen J, Jiang J-G. (2016) Chinese medicines with sedative–hypnotic effects and their active components. Sleep Medicine Reviews. 29:108-118.

Yadav V, Chatterjee SS, Majeed M, Kumar V. (2016) Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain. Journal of Traditional and Complementary Medicine. 6(4):413-423.

Cho S, Shimizu M. (2015) Chapter 15 – Natural Sleep Aids and Polyphenols as Treatments for Insomnia. Editor(s): Ronald Ross Watson, Victor R. Preedy. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Academic Press. 141-151.

Mao Q-Q, Xian Y-F, Ip S-P, Che C-T. (2011) Involvement of serotonergic system in the antidepressant-like effect of piperine. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 35(4):1144-1147.

Zhao M, Ma Y, Wei Z-Z, Yuan W-X, Li Y-L, Zhang C-H, Xue X-t, Zhou H-j. (2011) Determination and Comparison of γ-Aminobutyric Acid (GABA) Content in Pu-erh and Other Types of Chinese Tea. J. Agric. Food Chem. 59 (8):3641–3648. DOI: 10.1021/jf104601v

Silber BY, Schmitt JAJ. (2010) Effects of tryptophan loading on human cognition, mood, and sleep. Neuroscience & Biobehavioral Reviews. 34(3):387-407.

Srivastava, J. K., Shankar, E., & Gupta, S. (2010) Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports. 3(6): 895–901.

Pawlyk AC, Alfinito PD, Johnston GH, Deecher DC. (2008) Subchronic 17α-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats. Hormones and Behavior. 53(1):217-224.

Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y. (2007) Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sciences. 80(15):1373-1381.

Bjork M.J., Moeller F.G., Kramer L.G., Kram M., Suris A., Rush A.J. and Petty F. (2001) Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. Psychiatry Research. 101(2): 131–136.

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