RELATED RESEARCH
Cordyceps Benefits
Related to virus suppressor
- Ryu, E, Son, M, Lee, M, Lee, K, Cho, JY, Cho, S, … Kang, H. (2014) Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication. Oncoscience, 1(12): 866–881. http://doi.org/10.18632/oncoscience.110
- Zhang, H.; Saravanan, K.M.; Yang, Y.; Hossain, M.T.; Li, J.; Ren, X.; Wei, Y. Deep Learning Based Drug Screening for Novel Coronavirus 2019-nCov. Preprints 2020, 2020020061. http://doi.org/10.20944/preprints202002.0061.v1
Related to immunity and cancer studies
- Nakamura K, Shinozuka K, Yoshikawa N. (2015) Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. Journal of Pharmacological Sciences. 127(1): 53-56. https://doi.org/10.1016/j.jphs.2014.09.001
- Niwa Y, Matsuura H, Murakami M, Sato J, Hirai K, Sumi H. (2013) Evidence that Naturopathic Therapy including Cordyceps sinensis Prolongs Survival of Patients with Hepatocellular Carcinoma. Integr Cancer Ther. 12(1): 50-68. https://doi.org/10.1177/1534735412441704
- Choi S, Lin MH, Kim KM, Jeon BH, Song WO, Kim TW. (2011) Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor. Toxicol ApplPharmacol. 257(2): 165-173. https://doi.org/10.1016/j.taap.2011.08.030
- Jordan JL, Nowak A, Lee TD. (2010) Activation of innate immunity to reduce lung metastases in breast cancer. Cancer Immunol Immunother. 59(5): 789-797. https://doi.org/10.1007/s00262-009-0800-x
- Yoshikawa N, Nakamura K, Yamaguchi Y, Kagota S, Shinozuka K, Kunitoma M. (2007) Cordycepin and Cordyceps sinensis reduce the growth of the human promyelocytic leukaemia cells through the Wnt signaling pathway. Clin Exp Pharmacol Physiol. 34: S61-S63. https://doi.org/10.1111/j.1440-1681.2007.04781.x
- Kuo YC, Lin CY, Tsai WJ, WU CL, Chen CF, Shiao MS. (1994) Growth inhibitors against tumor cells in Cordyceps sinesis other than cordycepin and polysaccharides. Cancer Invest. 12(6): 611-615. https://doi.org/10.3109/07357909409023046
Cordyceps Benefits on Increased Oxygen at tissue level (i.e. Hypoxia)
- Singh M, Tulsawani R, Koganti P, Chauhan A, Manickam M, Misra K. (2013) Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells. BioMed Research International. 2013, 569206. http://doi.org/10.1155/2013/569206
Cordyceps Benefits on Exercise Performance (Anti-fatigue)
- Xu YF. (2016) Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming. Int J Med Mushrooms. 18(12):1083-1092. 10.1615/IntJMedMushrooms.v18.i12.30
- Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. (2010) Effect of Cs-4®(Cordyceps sinensis) on exercise performance in healthy older subjects : A double-blind, Placebo-Controlled Trial. J Altern Complement Med. 16(5): 585-590. http://doi.org/10.1089/acm.2009.0226
- Nagata A, Tajima T, Uchida M. (2006) Supplemental anti-fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human. Jpn J Phys Fitness Sports Med. 55: 145-151. https://doi.org/10.7600/jspfsm.55.S145
Cordyceps Benefits on Kidney function
- Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. (2014) Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease. Cochrane Database of Systematic Reviews. Issue 12. Art. No.: CD008353. https://doi.org//10.1002/14651858.CD008353.pub2
- Xu FL, Huan WY, Wu TX, Qiu X, Zhang H, Liu XH. (2006) Clinical efficacy of Cordyceps sinensis for chronic kidney diseases: a systematic review. Chinese Journal of Evidence-Based Medicine. 6(11): 804-808. https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0023865/
- Zhu JG, Halpern G, Jones K. (1998) The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordycep sinensis. The Journal of Alternative and Complimentary Medicine. 4(3): 289-303, 429-457. https://doi.org/10.1089/acm.1998.4.3-289
- Guan YJ, Hu Z, Hou M. (1992) Effect of Cordycep sinensis on T-lymphocyte subsets in chronic renal failure. ZhongguoZhong Xi Yi Jie He Za Zhi. 12: 338-339, 323. https://www.ncbi.nlm.nih.gov/pubmed/1421972
Cordyceps Benefits on Liver Functions
- Liu YK, Shen W. (2003) Inhibitive effect of Cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. World J Gastroenterol. 9: 529-33. https://www.ncbi.nlm.nih.gov/pubmed/12632512?dopt=Abstract
- Gong HY, Wang KQ, Tang SG. (2000) Effects of Cordyceps sinensis on T lymphocyte subsets and hepatic fibrosis in patients with chronic hepatitis B. Hunan Yi Ke Da Xue Xue Bao. 25: 248-250. https://www.ncbi.nlm.nih.gov/pubmed/12212155
- Zhao SL. (2000) Advance of treatment for Cordyceps on chronic hepatic diseases. Shanxi Zhong Yi. 16: 59-60.
Cordyceps Benefits on Immunosuppressive Therapy
- Ding C, Tian P-x, Xue W, Ding X, Yan H, Pan X, Feng X, Xiang H, Hou J, Tian X. (2011) Efficacy of Cordyceps sinensis in long term treatment of renal transplant patients. Front Biosci (Elite Ed). 3: 301-7. https://www.bioscience.org/2011/v3e/af/245/fulltext.htm
- Li Y, Xue WJ, Tian PX, Ding XM, Yan H, Pan XM, Feng XS. (2009) Clinical Application of Cordyceps sinensis on Immunosuppressive Therapy in Renal Transplantation. Tranplant Proc. 41(5): 1565-1569. https://doi.org/10.1016/j.transproceed.2009.02.085
Cordyceps Benefits on Respiratory Pathway
- Ma X, Jiao X, Wu J, Zhao J, Xu Y, Liu T, Xu J, Yang L, Dong L. (2018) The Function of Ophiocordyceps sinensis in Airway Epithelial Cell Senescence in a Rat COPD Model. Canadian Respiratory Journal. 2018, 6080348. http://doi.org/10.1155/2018/6080348
- Liu A, Wu J, Li A, Bi W, Liu T, Cao, L, Lui Y, Dong L. (2016) The inhibitory mechanism of Cordyceps sinensis on cigarette smoke extract-induced senescence in human bronchial epithelial cells. International Journal of Chronic Obstructive Pulmonary Disease. 11: 1721–1731. http://doi.org/10.2147/COPD.S107396
Cordyceps Benefits on arthritis
- Noh E-M, Kim J-S, Hur H, Park B-H, Song E-K, Han M-K, Kwon K-B, Yool W-H, Shim -K, Lee SJ, Youn HJ, Lee Y-R. (2009) Cordycepin inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology. 48(1): 45–48. https://doi.org/10.1093/rheumatology/ken417
Cordyceps Benefits on Male Reproductive System
- Chen Y-C, Chen Y-H, Pan B-S, Chang M-M, Huang B-M. (2017) Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review. Journal of Food and Drug Analysis. 25(1) :197-205. https://doi.org/10.1016/j.jfda.2016.10.020.
Cordyceps Benefits related to UVB protection on Skin
- Wong WC, WC JY, Benzie IF. (2011) Photoprotective potential of Cordyceps Polysaccharides against ultraviolet B radiation-induced DNA damage to human skin cells. Br J Dermatol. 164(5): 980-986. https://doi.org/10.1111/j.1365-2133.2010.10201.x
- Lee YR, Noh EM, Jeong EY, Yun SK, Jeong YJ, Kim JH, Kwon KB, Kim BS, Lee SH, Park CS, Kim JS. (2009) Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-KB pathway in human dermal fibroblast. Exp Mol Med. 41(8): 548-554. https://www.nature.com/articles/emm200962
Cordyceps Benefits on Anti-inflammation
- Park S-Y, Jung S-J, Ha K-C, Sin H-S, Jang S-H, Chae H-J, Chae S-W (2015) Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages. Oriental Pharmacy and Experimental Medicine. 15(1): 7–12. http://doi.org/10.1007/s13596-014-0173-3
- Yang ML, Kuo PC, Hwang TL, Wu TS. (2011) Anti-inflammatory principles from Cordyceps sinensis. J Nat Prod.74 (9): 1996-2000. http://doi.org/10.1021/np100902f
- Li CY, Chiang CS, Tsai ML, Hseu RS, Shu WY, Chuang CY, Sun YC, Chang YS, Lin JG, Chen CS, Huang CL, Hsu IC. (2009) Two-sided effect of Cordyceps sinensis on dendritic cells in different physiological stages. J Leukoc Biol. 85(6): 987-995. https://doi.org/10.1189/jlb.0908573
Cordyceps Benefits on Anti-oxidation
- Li SP, Li P, Dong TTX, Tsin KW. (2001) Anti-oxidant activity of different type of natural Cordyceps sinensis and cultured Cordyceps mycelia. Phytomedicine. 8(3): 207-212. https://doi.org/10.1078/0944-7113-00030
Cordyceps Benefits on cholesterol by lowering LDL
- Gao J, Lian ZQ, Zhu P, Zhu HB. (2011) Lipid-lowering effect of cordycepin (3′-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats. Yao Xue Xue Bao. 46(6): 669-76. https://www.ncbi.nlm.nih.gov/pubmed/21882527
- Guo P, Kai Q, Gao J, Lian ZQ, Wu CM, Wu CA, Zhu HB. (2010) Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharmacol Sci. 113(4): 395-403. https://www.ncbi.nlm.nih.gov/pubmed/20724804
- Koh J-H, Kim J-M, Chang U-J, Suh H-J. (2003) Hypocholesterolemic Effect of Hot-Water Extract from Mycelia of Cordyceps sinensis. Biological and Pharmaceutical Bulletin. 26(1): 84-87. https://doi.org/10.1248/bpb.26.84
Cordyceps Benefits on Blood Sugar
- Yu SH, Chen SY, Li WS, et al. (2017) Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice. J Diabetes Res. 2017:7947401. https://doi.org/10.1155/2017/7947401
- Liu C, Song J, Teng M, Zheng X, Li X, Tian Y, Pan M, Li Y, Lee RJ, Wang D.(2016) Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps militaris Fruit Body in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Oxidative Medicine and Cellular Longevity. E-Pub 2016:9685257: 11 pp. http://dx.doi.org/10.1155/2016/9685257
- Lo HC, Tu ST, Lin KC, Lin SC. (2004) The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin. Life Sci. 74(23): 2897-2908. https://doi.org/10.1016/j.lfs.2003.11.003
Sesame with Gotu Kola, Collagen type II and Soy Protein Isolate
Srisuthtayanont W, Pruksakorn D, Kongtawelert P, Pothacharoen P. (2017) Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes. BMC Complementary and Alternative Medicine. 17:286. https://doi.org/10.1186/s12906-017-1805-1
Khansai M, Boonmaleerat K, Pothacharoen P, Phitak T, Kongtawelert P. (2016) Ex vivo model exhibits protective effects of sesamin against destruction of cartilage induced with a combination of tumor necrosis factor-alpha and oncostatin M. BMC Complementary and Alternative Medicine16:205. https://doi.org/10.1186/s12906-016-1183-0
Sharma S, Gupta R, Thakur SC. (2014) Attenuation of collagen induced arthritis by Centella asiatica methanol fraction via modulation of cytokines and oxidative stress. Biomed Environ Sci.27(12):926-38. https://doi.org/10.3967/bes2014.133
Crowley DC, Lau FC, Sharma P. (2009) Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. International J of Med Sciences. 6:312-321. https://doi.org/10.7150/ijms.6.312
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Sesame, Rice bran, Chamomile flower with Cordyceps, Green tea and Black pepper
Isadora Braga Contreiras Carneiro, Ana Elisa Toscano, Diego Cabral Lacerda, Marcela de Sá Barreto da Cunha, Raul Manhães de Castro, Tereza Cristina Bonfim de Jesus Deiró, Jairza Maria Barreto Medeiros. (2018) L-tryptophan administration and increase in cerebral serotonin levels: Systematic review. European Journal of Pharmacology. Article in Press. https://doi.org/10.1016/j.ejphar.2018.08.009.
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Cho S, Shimizu M. (2015) Chapter 15 – Natural Sleep Aids and Polyphenols as Treatments for Insomnia. Editor(s): Ronald Ross Watson, Victor R. Preedy. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Academic Press. 141-151. https://doi.org/10.1016/B978-0-12-411462-3.00015-1.
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Zhao M, Ma Y, Wei Z-Z, Yuan W-X, Li Y-L, Zhang C-H, Xue X-t, Zhou H-j. (2011) Determination and Comparison of γ-Aminobutyric Acid (GABA) Content in Pu-erh and Other Types of Chinese Tea. J. Agric. Food Chem. 59 (8):3641–3648. DOI: 10.1021/jf104601v
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Pawlyk AC, Alfinito PD, Johnston GH, Deecher DC. (2008) Subchronic 17α-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats. Hormones and Behavior. 53(1):217-224. https://doi.org/10.1016/j.yhbeh.2007.09.018.
Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y. (2007) Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sciences. 80(15):1373-1381. https://doi.org/10.1016/j.lfs.2006.12.027.
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