Related to virus suppressor
Related to immunity and cancer studies
Cordyceps Benefits on Increased Oxygen at tissue level (i.e. Hypoxia)
Cordyceps Benefits on Exercise Performance (Anti-fatigue)
Cordyceps Benefits on Kidney function
Cordyceps Benefits on Liver Functions
Cordyceps Benefits on Immunosuppressive Therapy
Cordyceps Benefits on Respiratory Pathway
Cordyceps Benefits on arthritis
Cordyceps Benefits on Male Reproductive System
Cordyceps Benefits related to UVB protection on Skin
Cordyceps Benefits on Anti-inflammation
Cordyceps Benefits on Anti-oxidation
Cordyceps Benefits on cholesterol by lowering LDL
Cordyceps Benefits on Blood Sugar
Cordyceps sinensis, the main ingredient in CORDYTHAI with Collagen
Glutathione Benefits
Matsuki M, Watanabe T, Ogasara A, Mikami T, Matsumoto T. (2008) Inhibitory Mechanism of Melanin Synthesis by Glutathione. Yakugaku Zasshi. 128(8): 1203-1207. https://doi.org/10.1248/yakushi.128.1203
Collagen Benefits
Moskowitz R. (2000) Role of collagen hydrolysate in bone and joint disease. Seminass in arthritis and rheumatism. 30(2): 87-99. https://doi.org/10.1053/sarh.2000.9622
Arginine Benefits
Roth AJ, Muller O, Schopohl J, von Werder K. (1998) Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 67(6): 1186-1189. https://doi.org/10.1210/jcem-67-6-1186
Glucan Benefits
Vetvika V, Dvorak B, Vetvickova J, Richter J, Krizan J, Sima P, Yvin JC. (2007) Orally administered marian (1,3)-beta-D-Glucan Phycarine stimulates both humoral and cellular immunity. Intl J Biol Macromolec. 40(4): 291-298. https://doi.org/10.1016/j.ijbiomac.2006.08.009
Kirmaz C, Bayrak P, Yilmaz O, Yuksel H. (2005) Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis : a double-blind placebo-controlled study. European cytokine network. 16(2): 128-134. https://www.ncbi.nlm.nih.gov/pubmed/15941684
Black Ginger (KraChaiDam) Benefits
Toda, K., Hitoe, S., Takeda, S., & Shimoda, H. (2016). Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolism. Heliyon, 2(5), e00115. http://doi.org/10.1016/j.heliyon.2016.e00115
Temkitthawon P, Hinds TR, Beavo JA, Viyoch J, Suwanborirux K, Pongamornkul W, Sawasdee P, Ingkaninan K. (2011). Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. Journal of Ethnopharmacology. 137(3): 1437–1441. http://doi.org/10.1016/j.jep.2011.08.025
Pojanagaroon S, Rujjanawate C. (2005) Effect of internal color of Kaempferia parviflora (Krachai-Dam) rhizomes as raw materials for wine processing on anti-oxidative activity. Processding of 43rd Kasetsart University Annual Conference. Thailand. 1-4 February.
Black Ginger (Krachidam กระชายดำ) one of the ingredients in CORDYTHAI with Black Ginger
Srisuthtayanont W, Pruksakorn D, Kongtawelert P, Pothacharoen P. (2017) Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes. BMC Complementary and Alternative Medicine. 17:286. https://doi.org/10.1186/s12906-017-1805-1
Khansai M, Boonmaleerat K, Pothacharoen P, Phitak T, Kongtawelert P. (2016) Ex vivo model exhibits protective effects of sesamin against destruction of cartilage induced with a combination of tumor necrosis factor-alpha and oncostatin M. BMC Complementary and Alternative Medicine16:205. https://doi.org/10.1186/s12906-016-1183-0
Sharma S, Gupta R, Thakur SC. (2014) Attenuation of collagen induced arthritis by Centella asiatica methanol fraction via modulation of cytokines and oxidative stress. Biomed Environ Sci.27(12):926-38. https://doi.org/10.3967/bes2014.133
Crowley DC, Lau FC, Sharma P. (2009) Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. International J of Med Sciences. 6:312-321. https://doi.org/10.7150/ijms.6.312
Hyun TH, Barrett-Connor E, Milne DB. (2004) Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study. The American Journal of Clinical Nutrition. 80(3): 715–721. https://doi.org/10.1093/ajcn/80.3.715
Bagchi D, Misner B, Bagchi M, Kothari SC. (2002) Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 22(3-4):101-110. https://www.ncbi.nlm.nih.gov/pubmed/12837047
Ausar S, Beltramo D, Castagna L, Quintana S. (2001) Treatment of rheumatoid arthritis by oral administration of bovine tracheal type II collagen. Rheumat Intern. 20(4):138-144. https://www.ncbi.nlm.nih.gov/pubmed/11411957
Garcia G, Komagata Y, Slavin A, Maron R, Weiner H. (1999) Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen. J of Autoimmunity. 13(3): 315-324. https://doi.org/10.1006/jaut.1999.0320
Chavali R, Zhong SW, Tsunomiya WU, Robert TF. (1997) Decreased Production of lnterleukin-1-Beta, Prostaglandin-E2 and Thromboxane-B2, and Elevated Levels of lnterleukin-6 and -10 Are Associated with Increased Survival during Endotoxic Shock in Mice Consuming Diets Enriched with Sesame Seed Oil Supplemented with Quil-A Saponin. International archives of allergy and immunology. 114. https://doi.org/10.1159/000237661
Bonte F, Dumas M, Chaudagne C, Meybeck A. (1994) Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. Planta Med. 60(2):133-135. https://doi.org/10.1055/s-2006-959434
Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D. (1993) Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 261(5129):1727-1730. https://www.ncbi.nlm.nih.gov/pubmed/8378772
Black sesame seeds, source of sesamin. One of the ingredients in CENTRO joint support
Isadora Braga Contreiras Carneiro, Ana Elisa Toscano, Diego Cabral Lacerda, Marcela de Sá Barreto da Cunha, Raul Manhães de Castro, Tereza Cristina Bonfim de Jesus Deiró, Jairza Maria Barreto Medeiros. (2018) L-tryptophan administration and increase in cerebral serotonin levels: Systematic review. European Journal of Pharmacology. Article in Press. https://doi.org/10.1016/j.ejphar.2018.08.009.
Zhigang L, Liu X, Luo S, Chu C, Wu D, Liu R, Wang L, Wang J, Liu X. (2018) Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits. Journal of Functional Foods. 42:237-247. https://doi.org/10.1016/j.jff.2018.01.005.
Adib-Hajbaghery M, Mousavi SN. (2017) The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complementary Therapies in Medicine. 35:109-114. https://doi.org/10.1016/j.ctim.2017.09.010.
Bjorness TE, Greene RW. (2017) Chapter 6 - Sleep, Adenosine, and Neurodegeneration. Editor(s): David Blum, Luísa V. Lopes. Adenosine Receptors in Neurodegenerative Diseases. Academic Press. 111-130. https://doi.org/10.1016/B978-0-12-803724-9.00006-5.
Greene RW, Bjorness TE, Suzuki A. (2017) The adenosine-mediated, neuronal-glial, homeostatic sleep response. Current Opinion in Neurobiology. 44:236-242. https://doi.org/10.1016/j.conb.2017.05.015.
Shi M-M, Piao J-H, Xu X-L, Zhu LC, Yang L, Lin F-L, Chen J, Jiang J-G. (2016) Chinese medicines with sedative–hypnotic effects and their active components. Sleep Medicine Reviews. 29:108-118. https://doi.org/10.1016/j.smrv.2015.10.001.
Yadav V, Chatterjee SS, Majeed M, Kumar V. (2016) Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain. Journal of Traditional and Complementary Medicine. 6(4):413-423. https://doi.org/10.1016/j.jtcme.2015.11.001.
Cho S, Shimizu M. (2015) Chapter 15 - Natural Sleep Aids and Polyphenols as Treatments for Insomnia. Editor(s): Ronald Ross Watson, Victor R. Preedy. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Academic Press. 141-151. https://doi.org/10.1016/B978-0-12-411462-3.00015-1.
Mao Q-Q, Xian Y-F, Ip S-P, Che C-T. (2011) Involvement of serotonergic system in the antidepressant-like effect of piperine. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 35(4):1144-1147. https://doi.org/10.1016/j.pnpbp.2011.03.017.
Zhao M, Ma Y, Wei Z-Z, Yuan W-X, Li Y-L, Zhang C-H, Xue X-t, Zhou H-j. (2011) Determination and Comparison of γ-Aminobutyric Acid (GABA) Content in Pu-erh and Other Types of Chinese Tea. J. Agric. Food Chem. 59 (8):3641–3648. DOI: 10.1021/jf104601v
Silber BY, Schmitt JAJ. (2010) Effects of tryptophan loading on human cognition, mood, and sleep. Neuroscience & Biobehavioral Reviews. 34(3):387-407. https://doi.org/10.1016/j.neubiorev.2009.08.005.
Srivastava, J. K., Shankar, E., & Gupta, S. (2010) Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports. 3(6): 895–901. http://doi.org/10.3892/mmr.2010.377
Pawlyk AC, Alfinito PD, Johnston GH, Deecher DC. (2008) Subchronic 17α-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats. Hormones and Behavior. 53(1):217-224. https://doi.org/10.1016/j.yhbeh.2007.09.018.
Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y. (2007) Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sciences. 80(15):1373-1381. https://doi.org/10.1016/j.lfs.2006.12.027.
Bjork M.J., Moeller F.G., Kramer L.G., Kram M., Suris A., Rush A.J. and Petty F. (2001) Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. Psychiatry Research. 101(2): 131–136.
Chamomile flower one of the natural ingredients in PABLO natural sleep aid
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